Electric Literature of 954220-98-5 , The common heterocyclic compound, 954220-98-5, name is 2,4-Dichloro-5-fluoro-6-methylpyrimidine, molecular formula is C5H3Cl2FN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Compound 1b (0.130 g, 0.718 mmol), compound Int-1 (0.204 g, 0.718 mmol)And DIPEA (0.401 g, 2.730 mmol) were sequentially added to tetrahydrofuran (30 mL)And absolute ethanol (2 mL), heated to reflux and stirred for 12 h. Quench with water,Extract twice with ethyl acetate (30 mL), combine the ethyl acetate layers,It was washed with saturated brine (30 mL), dried over anhydrous sodium sulfate, and concentrated to dryness under reduced pressure.Silica gel column chromatography (PE / EA = 20/1 to 10/1) was purified to obtain 0.115 g of pale yellow oil,That is, compound 1c.
The synthetic route of 954220-98-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Yinxingshu Pharmaceutical (Suzhou) Co., Ltd.; Chen Li; Shao Qing; Gan Libin; (22 pag.)CN110590768; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia