Related Products of 2927-71-1, Adding some certain compound to certain chemical reactions, such as: 2927-71-1, name is 2,4-Dichloro-5-fluoropyrimidine,molecular formula is C4HCl2FN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2927-71-1.
Add the third step product, 5-fluoro-1,1-dimethyl-7- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) -2,3-dihydro-1H-benzo [d] pyrrole [1,2-a] imidazole (1.2 g, 3.6 mmol)to the reaction flask,2,4-dichloro-5-fluoropyrimidine (0.664 g, 4.0 mmol) Pd (PPh3) 2Cl2 (282 mg, 0.40 mmol), Sodium carbonate (763 mg, 7.2 mmol) and DME / H2O (40 mL / 10 mL). In a nitrogen atmosphere, the mixture was stirred at 80 C for 3 hours. Cooling to room temperature, the reaction solution suction filter, The filtrate was concentrated in vacuo. The resulting residue was purified by silica gel column chromatography (ethyl acetate / petroleum ether = 1/3) To give the title compound (0.51 g, white solid) in 42% yield.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Gan & Lee Pharmaceuticals; Liu, Wenjian; Yin, Lei; Li, Heng; (94 pag.)CN106608879; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia