In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13544-44-0, name is 2,4-Dichloro-5-iodopyrimidine, the common compound, a new synthetic route is introduced below. SDS of cas: 13544-44-0
The mixture of 2,4-dichloro-5-iodopyrimidine (400 mg) and N-(3-aminopropyl)carbamic acid tert-butyl ester (0.24 ml) in 3 ml of ACN with 0.23 ml od TEA was stirred overnight at rt. The product was then precipitated by the addition of water and collected and dried as an opaque yellow oil. 20 mg of this product was then reacted with N-(3-aminophenyl)pyrrolidine-1-carboxamide (14.9 mg, prepared previously28) overnight at 115C in 1 ml of MeOH in a sealed vial with 1.5 mul concn HCl. Then 1 ml of TFA was added overnight at rt to deprotect. The product was then purified by RP HPLC to give the final product, which was then lyophilized to give a white powder. Overall yield of 16%.
The synthetic route of 13544-44-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Lazarus, Michael B.; Shokat, Kevan M.; Bioorganic and Medicinal Chemistry; vol. 23; 17; (2015); p. 5483 – 5488;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia