Reference of 49845-33-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.49845-33-2, name is 2,4-Dichloro-5-nitropyrimidine, molecular formula is C4HCl2N3O2, molecular weight is 193.9756, as common compound, the synthetic route is as follows.
[00235] Example 5.1 Synthesis of 4-({8-[(2,6-Difluorophenyl)amino]-9- cvclopentylpurin-2-yl) amino) frvms-cyclohexan-l-ol; [00236] 1. (2-Chloro-5-nitropyrimidin-4-yl’)cvclopentylamine; [00237] 2,4-Dichloro-5-nitropyrimidine (10.31 mmol, 2 g) and cyclopentylamine(10.31 mmol, 1.02 mL) were dissolved in THF (60 mL) and cooled to -78C. N5N- diisopropylethylamine (10.31 mmol, 1.8 mL) was added dropwise. The reaction mixture was stirred at -78C for about 45 minutes. The cooling bath was removed and the reaction mixture was stirred at room temperature for about 16 hours. After removal of the solvent the residue was redissolved in EtOAc and washed with water and brine. The organic phase was dried over MgSO4 and the solvent evaporated. The residue was purified using column chromatography (SiO2, 9:1 n-hexanes/ ethyl acetate) to give the desired product (2.11 g, 84% yield). ES-MS: 242 (M+l). When the hydrochloride salt of an amine is used in place of the cyclopentylamine described above, 2 to 3 equivalents of N,N-diisopropylethylamine and dichloromethane are used as solvent.
Statistics shows that 49845-33-2 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichloro-5-nitropyrimidine.
Reference:
Patent; SIGNAL PHARMACEUTICALS, LLC; WO2006/76595; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia