Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1780-32-1, name is 2,4-Dichloro-5,6-dimethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 1780-32-1
To a solution of 2,4-dichloro-5,6-dimethylpyrimidine (0.800 g, 4.55 mmol) in EtOH (40 mL) were added Na2CO3 (2.42 g, 22.8 mmol) and 1H-indazol-5-amine (0.605 g, 4.55 mmol). The resulting mixture was stirred for 12 h at 100 C. The solvent was removed under reduced pressure and the residue was poured into water (50 mL) and extracted with EtOAc (3 x 100 mL). The organic phase was dried over Na2 SO4, filtered and concentrated under reduced pressure to give a residue which was purified by column chromatograph on silica gel (eluted with PEEA = 1:1) to provide the title compound (120 mg, yield: 9.7%) as a white solid.
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Reference:
Patent; KADMON CORPORATION, LLC; KIM, Ji-in; LIU, Kevin; POYUROVSKY, Masha; LU, Dan; ZHU, Zhenping; WO2015/54317; (2015); A1;,
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