Synthetic Route of 63200-54-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 63200-54-4, name is 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine, molecular formula is C6H3Cl2N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Preparation method reference Example 1, wherein,Cyclopropylamine is replaced with cyclobutylamine,The reaction temperature is increased from 30 C to reflux. Got a white solid. Yield: 80%. 2,4-Dichloro-5H-pyrrolo [3,2-d] pyrimidine (600 mg, 3.19 mmol) was placed in a round bottom flask,Tetrahydrofuran THF (20 mL) was added to dissolve, and cyclopropylamine (218 mg, 3.83 mmol) and N-diisopropylethylamine DIEA (823 mg, 6.38 mmol)30 C reaction 24h. Treatment: The reaction mixture was removed under reduced pressure,The residue was subjected to column chromatography (petroleum ether: ethyl acetate = 2: 1) to give a white solid. Yield: 63%.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 63200-54-4, 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine.
Reference:
Patent; Zhengzhou University The First Affiliated Hospital; Kan Quancheng; Tian Xin; Zhang Xiaojian; Cheng Weiyan; Du Yue; Yang Zhiheng; Yuan Yongliang; (12 pag.)CN107312006; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia