The origin of a common compound about 2,4-Dichloro-6-methoxypyrimidine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 43212-41-5, 2,4-Dichloro-6-methoxypyrimidine, other downstream synthetic routes, hurry up and to see.

Electric Literature of 43212-41-5 ,Some common heterocyclic compound, 43212-41-5, molecular formula is C5H4Cl2N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 2,4-dichloro-6-methoxypyrimidine (560mg, 3.1mmol), S-2-[3-(pyrimidin-2-yl)isoxazol-5-yl]pyrrolidine (680mg, 3.1mmol) and DIPEA (1.1ml, 6.3mmol) in 2-propanol (25ml) was heated at 120C for 18 hours. The volatiles were removed by evaporation and the residue purified by column chromatography on silica gel eluting with EPO EtOAc/hex (45:55) to give S-4-chloro-6-methoxy-2-{2-[3-(pyrimidin-2-yl)isoxazol-5- yl]pyrrolidin-l-yl}rhoyrimidine (600mg, 53%); m/z 359 [MH]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 43212-41-5, 2,4-Dichloro-6-methoxypyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/31745; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia