The origin of a common compound about 2,4-Dichloropyrido[2,3-d]pyrimidine

With the rapid development of chemical substances, we look forward to future research findings about 126728-20-9.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 126728-20-9, name is 2,4-Dichloropyrido[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 2,4-Dichloropyrido[2,3-d]pyrimidine

Intermediate 8 (200 mg, 0.584 mmol) was dissolved in ethanol (10 mL), then 2,4-dichloropyrido[2,3-d]pyrimidine 24 (117 mg, 0.58 mmol) and triethylamine (177 mg,1.75 mmol) were added. The resulting mixture was stirred at 90C for 12 hours. The solvent was evaporated. This crude product was purified by column chromatography over silica gel (eluent: methanol ethyl acetate ll0). The resulting residue waslyophilized to yield a white solid (78.3 mg, 27%).

With the rapid development of chemical substances, we look forward to future research findings about 126728-20-9.

Reference:
Patent; JANSSEN SCIENCES IRELAND UC; TAHRI, Abdellah; VENDEVILLE, Sandrine, Marie, Helene; JONCKERS, Tim, Hugo, Maria; RABOISSON, Pierre, Jean-Marie, Bernard; DEMIN, Samuel, Dominique; HU, Lili; COOYMANS, Ludwig, Paul; (105 pag.)WO2016/91774; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia