Related Products of 26305-13-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 26305-13-5, name is 2,4-Dihydroxy-5,6-dimethylpyrimidine, molecular formula is C6H8N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: 1,3-Dibenzoyl-6-methyluracil (3). To a suspension of 6-methyluracil (5.0 g, 0.040 mol) in anhydrous MeCN (100 mL) and anhydrous pyridine (20 mL) benzoyl chloride (12.5 mL, 0.108 mol) was added in one portion and stirred at room temperature for 24 h. The reaction mixture was concentrated in vacuo at a bath temperature not exceeding 60 C, cooled and the residue partitioned between CHCl3(200 mL) and ice water (100 mL). The organic phase was separated, dried over sodium sulfate, filtered and evaporated in vacuo at a bath temperature not exceeding 60 C. The residue was crystallized from Et2O (25 mL) to give 10.0 g (76%) of compound 3 as a yellow crystalline solid with mp 80-82 .
According to the analysis of related databases, 26305-13-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Ozerov, Alexander; Novikov, Mikhail; Khandazhinskaya, Anastasiya; Solyev, Pavel; Heterocycles; vol. 94; 5; (2017); p. 912 – 922;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia