Reference of 4425-56-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 4425-56-3 as follows.
EXAMPLE 78 In 400 ml. of acetic acid is suspended 2.05 g. of 1,2,3,4-tetrahydro-2,4-dioxopyrimidine-5-carbonitrile and, with vigorous stirring a mixed gas of fluorine and nitrogen (15:85 (V/V)) is introduced. When about 1.5 molar equivalents to fluorine to the substrate has been introduced, the reaction mixture is evapolated to dryness. Ethanol (70 ml.) is added to the residue and the mixture is heated under reflux for 2 hours and, then, evapolated to dryness again. The resultant syrup is subjected to column chromatography on silica gel (solvent:benzene-acetone=4:1(V/V)) to recover 1.54 g. of 5-fluoro-6-ethoxy-1,2,3,4,5,6-hexahydro-2,4-dioxopyrimidine-5-carbonitrile as white crystals. Melting Point: 195-196 C. NMR spectrum (DMSO-d6) delta: 1.07(3H, t, J=7HZ), 3.64(2H, q*d, J=7HZ and J=2HZ), 5.42(1H, d*d, J=4HZ and J=2HZ), 9.38(1H, broad), 11.59(1H, broad). Elemental analysis, for C7 H8 FN3 O3: Calcd.: C, 41.80; H, 4.01; N, 20.89. Found: C, 41.44; H, 3.95; N, 20.70.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4425-56-3, its application will become more common.
Reference:
Patent; Takeda Chemical Industries, Ltd.; US4329460; (1982); A;,
Pyrimidine | C4H4N2 – PubChem,
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