Reference of 6693-08-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 6693-08-9 as follows.
Intermediate 17(4,6-Dichloro-5-fluoro-pyrimidin-2-yl)-(5-methoxy-lH-pyrazol-3-yl)-amine To the solution of 2,4,6-trichloro-5-fluoro-pyrimidine (PCT Pub. No. WO200549033, 1.66 g, 8.26 mmol) in EtOH (3OmL) at -300C was added 5-methoxy-lH-pyrazol-3-amine (Intermediate 8, 1.Og, 9.08 mmol). DIPEA (4.3 mL, 25 mmol) was added to the solution and the reaction mixture was naturally warmed to 00C for 3 hours and then at room temperature overnight. Evaporation of the solvents under reduced pressure, a white precipitate was removed by filtration. The mother liquid was evaporated to dryness and purified by silica gel chromatography (ISCO, DCM/MeOeta/Neta4Oeta: 100/0/0-100/3/0.3) to give the title compound (221mg, 10%). LCMS: 279 [M+H].
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6693-08-9, its application will become more common.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/132502; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia