Reference of 3764-01-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3764-01-0, name is 2,4,6-Trichloropyrimidine. A new synthetic method of this compound is introduced below.
A mixture of 2,4,6-trichloropyrimidine (1.Og, 5.4mmol), 3-amino-5-methyl-lH- pyrrazole (0.53g, 5.4mmol) and sodium carbonate (0.57g, 5.4mmol) in ethanol (25ml) was stirred at ambient temperature for 18 hours. Water was added and the resulting precipitate was collected by filtration, washed with water and a small amount of methanol and dried to give 2,6-dichloro-4-(5-methyl-lH-pyrazol-3-ylamino)pyrimidine (1.15g, 88%) as a colourless crystalline solid; NMR Spectrum 2.23 (s, 3Eta), 6.01 (s, IH), 7.24 (s, IH), 10.25 (br s, IH), 11.9 (br s, IH); Mass Spectrum 244 [MH]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3764-01-0, its application will become more common.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/100461; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia