With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.22715-27-1, name is 2,5-Diaminepyrimidine, molecular formula is C4H6N4, molecular weight is 110.12, as common compound, the synthetic route is as follows.SDS of cas: 22715-27-1
EXAMPLE 73. Synthesis of N-(2-Amino-Pyrimidin-5-vn-2-ChIoro-S-(3- Trifluoromethvl-BenzovlaimnoVBenzamide (Compound XXXV)XXXV[0254] A solution of intermediate 1 (Example 2) (380 mg, 1.11 mmol) in DCM was charged with CDMT (233 mg, 1.33 mmol), and NMM (0.3 mL, 2.73 mmol). After 1 hr of stirring, 2,5-diaminopyrimidine (121 mg, 1.10 mmol) was added and the solution was allowed to stir for 48 h. The mixture was concentrated and purified by HPLC to afford the title compound as a white solid (350 mg, 73%).[0255] 1H NMR (500 MHz, DMSOd6): delta 7.59 (d, J= 8.8 Hz, IH), 7.81 (t, J= 7.9 Hz, IH), 7.93 (dd, J= 8.8 Hz, J= 2.5 Hz, IH), 8.00 (d, J= 7.8 Hz, IH), 8.02 (d, J= 2.7 Hz, IH), 8.28 (d, J= 8.0 Hz, IH), 8.32 (s, IH), 8.54 (s, 2H), 10.45 (s, IH), 10.71 (s, IH). MS (ES+): m/z 436.0 (M+H)+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,22715-27-1, 2,5-Diaminepyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; TARGEGEN, INC.; WO2008/8234; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia