Application of 120977-94-8, Adding some certain compound to certain chemical reactions, such as: 120977-94-8, name is 2,6-Dichloro-3H-pyrimidin-4-one,molecular formula is C4H2Cl2N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 120977-94-8.
Step A 6-((1′-tert-Butoxycarbonyl-4,4′-bipiperidin)-1-yl)-2-chloro-3H-pyrimid-4-one A solution of 100 mg (0.61 mmol) of 2,6-dichloropyrimid-4-one (Helv. Chim. Acta 1989, 72, 738) and 246 mg (0.92 mmol) of 1-tert-butoxycarbonyl-4,4′-bipiperidine in 6 mL of EtOH was refluxed for 2.25 hours. After cooling the reaction with an ice bath, the resulting solid was filtered and dried to yield 126 mg (52%) of the title compound: Rf: 0.77 (90:10:1 v/v/v CH2Cl2/MeOH/NH4OH); 1H NMR (500 MHz, CD3OD) delta 1.12-1.85 (m, 19H), 2.62-2.67 (m, 2H), 2.87-2.92 (m, 2H), 4.13-4.15 (m, 2H), 4.53-4.55 (m, 2H), 5.74 (s, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 120977-94-8, 2,6-Dichloro-3H-pyrimidin-4-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Merck & Co., Inc.; US6498161; (2002); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia