In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 26032-72-4, name is 2,4-Dichloro-6-phenylpyrimidine, the common compound, a new synthetic route is introduced below. name: 2,4-Dichloro-6-phenylpyrimidine
To a solution of 2, 4-dichloro-6-phenylpyrimidine (1.52 g, 6.7 mmol) and (+/-) -trans-methyl 3-aminobicyclo [2.2.2] octane-2-carboxylate (1.84 g, 10.0 mmol) in N, N-dimethyl-acetamide (10 mL) was added potassium carbonate (0.92 g, 6.7 mmol) , and the mixture was stirred at rt overnight. To the reaction mixture was added water (50 mL) , and the resulting mixture was extracted with ethyl acetate (40 mL ¡Á 3) . The combined organic layers were washed with saturated brine (80 mL) , dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuo and the residue was purified by silica gel column chromatography (n-hexane/EtOAc (v/v) = 20/1-10/1) to give the title compound as a white solid (1.65 g, 66%) .[0560]MS (ESI, pos. ion) m/z: 372.2 [M+H]+;[0561]1H NMR (400 MHz, CDCl3) delta (ppm) : 8.04 -7.91 (m, 2H) , 7.51 -7.41 (m, 3H) , 6.78 (s, 1H) , 5.41 (s, 1H) , 4.32 (s, 1H) , 3.73 (s, 3H) , 2.38 (d, J = 5.1 Hz, 1H) , 2.07 (s, 1H) , 1.86 (m, 1H) , 1.73 (m, 1H) , 1.70 -1.60 (m, 4H) , 1.57 (m, 2H) , 1.51 -1.41 (m, 1H) .
The synthetic route of 26032-72-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; TANG, Changhua; REN, Qingyun; YIN, Junjun; YI, Kai; LEI, Yibo; WANG, Yejun; ZHANG, Yingjun; (0 pag.)WO2018/157830; (2018); A1;,
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