Related Products of 274693-26-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.274693-26-4, name is 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol, molecular formula is C26H32F2N6O4S, molecular weight is 562.63, as common compound, the synthetic route is as follows.
2 g of compound h, 50 mL of methanol, 3 mol/L of HCl 48 mL were added to the reaction flask at room temperature, and magnetically stirred until dissolved.Solution, the ice bath was cooled to below 20 C, and the reaction was stirred for 15 h. After the reaction of co is completed, 20 mL of a 1 mol/L NaOH aqueous solution is added thereto. The pH was adjusted to about 7.2, methanol was distilled off, and 50 mL of ethyl acetate was added. The aqueous layer was separated and the organic layer was washed with brine. Evaporate 20 mL of ethyl acetate, replenish 30 mL of ethyl acetate, repeat the operation twice, combine the filtrates, and distill off part of the acetic acid.Ethyl ester, 200 mL of isooctane was added thereto, and the temperature was slowly raised to 50 C by an oil bath, stirred at a constant temperature for 30 min, and cooled to 20 C.The product j was precipitated, and dried by filtration to obtain 1.2 g of a pale yellow powder. The yield was 90%, and the HPLC purity was 97.88%. Compound j Chemical name: (1S, 2S, 3R, 5S)-3-[7-{[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino}-5-( Propylthio)-3H-[1,2,3]-triazole[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-dialcohol.
The chemical industry reduces the impact on the environment during synthesis 274693-26-4, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Beijing Kanglisheng Pharmaceutical Development Co., Ltd.; Cheng Gang; (14 pag.)CN104059069; (2016); B;,
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