The origin of a common compound about 33034-67-2

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 33034-67-2, 2-Chloro-4-(trifluoromethyl)pyrimidine.

Reference of 33034-67-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33034-67-2, name is 2-Chloro-4-(trifluoromethyl)pyrimidine, molecular formula is C5H2ClF3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of tert-butyl 4-({ [4-(5-cyano-7-isopropyl- 1 ,3-benzoxazol-2- yl)benzoyl] amino }methyl)-4-isopropylpiperidine- 1 -carboxylate(35 mg, 0.064 mmol) in dichloromethane was added trifluoroacetic acid. The mixture was stirred overnight at room temperature and then concentrated in vacuo. To the residue were added of methanol (2 ml), potassium carbonate (45 mg, 0.326 mmol) and 2-chloro-4- (trifluoromethyl)pyrimidine (16 mul, 0.133 mmol). The mixture was heated to 50 0C and stirred at this temperature for 4 h, at which point LC/MS analysis showed a peak at the desired molecular weight. The reaction mixture was concentrated and then purified by flash chromatography on a Biotage Horizon, 25S column, eluting with 1 column volume of 100percent dichloromethane followed by a gradient of 0 to 100percent ethyl acetate in dichloromethane over 10 column volumes to provide the title compound (33 mg, 0.056 mmol, 87 percent yield). Mass spectrum (ESI) 591.1 (M+l). 1HNMR (500 MHz, CDCI3): 8.47 (d, J=4.5 Hz, IH), 8.33 (d, J=8.5 Hz, IH), 7.93 (s, IH), 7.92 (d, J= 8.5 Hz, 2H), 7.51 (s, IH), 6.71 (d, J=5.0 Hz, IH), 6.18 (br t, J = 6.0 Hz, IH), 4.18 (m, 2H), 3.65-3.75 (m, 4H), 3.47 (septet, J = 7.0 Hz, IH), 1.89 (septet, J=6.5 Hz, IH), 1.70 (m, 2H), 1.50- 1.60 (m, 2H), 1.46 (d, J = 6.5 Hz, 6H), 1.02 (d, J=7.0 Hz, 6H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 33034-67-2, 2-Chloro-4-(trifluoromethyl)pyrimidine.

Reference:
Patent; MERCK & CO., INC.; WO2008/156715; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia