Adding a certain compound to certain chemical reactions, such as: 332133-92-3, 4-(Tributylstannyl)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 4-(Tributylstannyl)pyrimidine, blongs to pyrimidines compound. Application In Synthesis of 4-(Tributylstannyl)pyrimidine
A mixture of 3 -(8-amino-S -bromo-2-(2-chloro-6-fluorobenzyl)-[1,2,4jtriazolo[1,5-ajpyrazin-6-yl)benzonitrile(51 mg, 0.11 mmol), CuT (4.2 mg,0.021 mmol), CsF (33 mg, 0.22 mmol), tetrakis(triphenylphosphine)palladium(0) (12mg, 0.012 mmol), and 4-(tributylstannyl)pyrimidine (49 mg, 0.13 mmol) in 1,4- dioxane (2 mL) was heated at 140 C for 1 h in a microwave reactor. The reaction mixture was concentrated under vacuum and the resulting residue was purified with flash chromatography to give the desired product as a light yellow oil. LC-MScalculated for C23H15C1FN8 (M+H): m/z = 457.1 found 457.1.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,332133-92-3, 4-(Tributylstannyl)pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; INCYTE CORPORATION; HOANG, Gia; WANG, Xiaozhao; CARLSEN, Peter Niels; GAN, Pei; LI, Yong; QI, Chao; WU, Liangxing; YAO, Wenqing; YU, Zhiyong; ZHU, Wenyu; (333 pag.)WO2020/10197; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia