Adding a certain compound to certain chemical reactions, such as: 33581-98-5, 4-(Hydroxymethyl)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 4-(Hydroxymethyl)pyrimidine, blongs to pyrimidines compound. Application In Synthesis of 4-(Hydroxymethyl)pyrimidine
To a mixture of 5-[4-(trifluoromethoxy)phenyl]-3H-l,3-benzoxazol-2-one (100 mg, 0.34 mmol), pyrimidin-4-ylmethanol (111.9 mg, 1.02 mmol) and PPh3 (177.7 mg, 0.68 mmol) in THF (6 mL) was added the DIAD (136.99 mg, 0.68 mmol) at 0 C and the mixture was stirred under N2 at 20 C for 16 hours. The mixture was concentrated to dryness, diluted with H20 (10 mL), and the mixture was extracted with EtOAc (10 mL x 2). The combined organic phase was washed with brine (10 mL), dried over Na2SC>4, filtered and the filtrate was concentrated to give the crude product. The crude product was purified by flash chromatography on silica gel (EtOAc in PE = 0% to 30% to 40% to 55%) to give the product (62.94 mg, 160.4 muiotaetaomicron, 47% yield) as colorless oil. 1H NMR OMSO-d6 400MHz deltaH = 9.09 (s, 1H), 8.79 (d, 1H), 7.74 (d, 2H), 7.63 – 7.59 (m, 2H), 7.51 – 7.41 (m, 4H), 5.30 (s, 2H). LCMS Rt = 1.27 min in 2 min chromatography, MS ESI calcd. for C19H13F3N3O3 [M+H]+ 388.1, found 387.8.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,33581-98-5, 4-(Hydroxymethyl)pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; PRAXIS PRECISION MEDICINES , INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; (244 pag.)WO2018/148745; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia