With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.37972-24-0, name is 2-Ethynylpyrimidine, molecular formula is C6H4N2, molecular weight is 104.11, as common compound, the synthetic route is as follows.Application In Synthesis of 2-Ethynylpyrimidine
To a solution of 235(100mg, 0.272rnrnoi) and 4(56.6mg, 0543mmo1) in 2OrnL of Et3N was added Pd(PPh3)2C12 (9.53mg, 0.0 i4mmol) and Cui (5.17mg, 0.O27mmol). The mixture was protected with N2 atmosphere, then was heated at 70¡ãC for 4 hours. TLC analysis showedcomplete conversion of starting material to major product. The reaction mixture was then concentrated in vacuo. The crude product was purified by Prep-HPLC to give the target product Compound 133(24mg, yield: 25.7percent).LCMS: m/z 345 (M+HY;111 NMR (400 MHz, CDCI3): oe 8.76 (d, J= 4.0 Hz, 2H), 754 . 7.52. (m, 211), 7.35 7.32 (m,211), 7 25 (t J 4 6 Hz 1TI) 6 52 (d, / 0 4 lTz 111), 2 P (d, 1 0 4 Hz, 311)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,37972-24-0, 2-Ethynylpyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; JIN, Xiaowei; (176 pag.)WO2017/117708; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia