Application of 37972-24-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 37972-24-0, name is 2-Ethynylpyrimidine, molecular formula is C6H4N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 223(200mg, 0.694mmol) and 4(80mg, 0.764mmol) in 2OmL of Et3N was addedPd(PPh3)2C12 (24.37mg, 0.O3SmrnoI) and CuT (13.22mg, 0.O69mmol). The mixture wasprotected under N2 atmosphere, then was heated at 70¡ãC for 24 hours. TLC analysis showed complete conversion of starting material to a major product. The reaction mixture was then concentrated in vacuo. The crude product was purified by Prep-HPLC to give the target product Compound 86(18mg, yield c. 80 percent,).LCMS: m/ 265 (M+H)?H N?Ik (400 Mhz ( D( i) cS 8 5 (d J 49 lIz, 211) 8 16 (s, 111) 96 (s ill) 69- 61 (m, 2H), 725-7.22 (in, 1H), 7.22-7.11 (m, 2H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 37972-24-0, 2-Ethynylpyrimidine.
Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; JIN, Xiaowei; (176 pag.)WO2017/117708; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia