The origin of a common compound about 4-(4-Bromophenyl)-2,6-diphenylpyrimidine

Statistics shows that 58536-46-2 is playing an increasingly important role. we look forward to future research findings about 4-(4-Bromophenyl)-2,6-diphenylpyrimidine.

Synthetic Route of 58536-46-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.58536-46-2, name is 4-(4-Bromophenyl)-2,6-diphenylpyrimidine, molecular formula is C22H15BrN2, molecular weight is 387.27, as common compound, the synthetic route is as follows.

250ml four-necked flask, under a nitrogen atmosphere,Add 0.01 mol of raw material A8, 0.025 mol of raw material B4,0.04 mol of sodium tert-butoxide, 2 x 10-4 mol of Pd2(dba)3,2×10-4 mol of tri-tert-butylphosphine, 150 ml of toluene,Heat reflux for 24 hours, sample the plate, reaction is complete;Cool naturally, filter, rotate the filtrate, pass the silica gel column,Got the target product 78,Purity 97.8%, yield 64.3%.

Statistics shows that 58536-46-2 is playing an increasingly important role. we look forward to future research findings about 4-(4-Bromophenyl)-2,6-diphenylpyrimidine.

Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Cai Xiao; Li Chong; Zhang Zhaochao; Tang Dandan; Zhang Xiaoqing; (53 pag.)CN107586299; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia