Application of 2227-98-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2227-98-7, name is 4-Aminopyrrolo[3,2-d]pyrimidine, molecular formula is C6H6N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
[0059] (2R)-2-[({4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl}methyl)amino]-3-[(4- chlorophenyl)sulfanyl]propan-l-ol (K.3). Compound K.2 (0.151 g, 0.59 mmol) was dissolved in MeOH (10 mL) and neutralized with Amberlyst A21 resin. The mixture was then passed through a short column of the same resin and eluted with MeOH to give the free amino form of K.2 as a yellow oil (129 mg). This was dissolved in tert-butanol (3 mL) then aq. formaldehyde solution (37%, 0.060 mL, 0.80 mmol) and 9-deazaadenine (0.080 g, 0.60 mmol) were added and the mixture stirred at 70 C for 16 h. Silica gel was added to absorb all the solvent then the solvent was evaporated and the residue purified by chromatography on silica gel (CHC13-7M NH3/MeOH, 92:8 then 85: 15) and the fractions containing the product were evaporated. The residue was further purified on silica gel (CHCl3-MeOH-28% aq. NH4OH, 92:8:0.5) to give K.3 as a colourless foam (0.022 g, 10%). XH NMR (500 MHz, CD3OD): delta 8.16 (s, 1H), 7.35 (s, 1H), 7.13-7.08 (m, 4H), 4.02 (d, J= 14.0 Hz, 1H), 3.92 (d, J = 14.0 Hz, 1H), 3.70 (dd, J= 11.3, 5.2 Hz, 1H), 3.66 (dd, J= 11.3, 5.2 Hz, 1H), 3.13 (dd, J = 13.8, 6.2 Hz, 1H), 2.92 (dd, J = 13.8, 6.9 Hz, 1H), 2.75 (m, 1H). 13C NMR (125.7 MHz, CD3OD, centre line delta 49.0): delta 152.0 (C), 150.8 (CH), 146.5 (C), 135.8 (C), 133.0 (C), 131.8 (CH), 129.8 (CH), 129.1 (CH), 115.5 (C), 114.4 (C), 63.5 (CH2), 57.0 (CH), 41.0 (CH2), 36.1 (CH2). ESI-HRMS calcd for Ci6H1835ClN5NaOS+ (M+Na)+, 386.0813, found 386.0816.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2227-98-7, 4-Aminopyrrolo[3,2-d]pyrimidine.
Reference:
Patent; ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY; SCHRAMM, Vern, L.; CLINCH, Keith; GULAB, Shivali, Ashwin; WO2015/123101; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia