Related Products of 14080-59-2, Adding some certain compound to certain chemical reactions, such as: 14080-59-2, name is 4-Chlorothieno[2,3-d]pyrimidine,molecular formula is C6H3ClN2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14080-59-2.
To a tetrahydrofuran (15 ml) solution of 4-chlorothieno [2,3-d] pyrimidine (200 mg, 1.17 mmol) was added 1-methylpiperazine(0.26 ml, 2.34 mmol) and sodium hydroxide(0.94 g, 2.34 mmol) was added, followed by heating under reflux for 6 hours.After distilling off the solvent of the reaction solution under reduced pressure, ethyl acetate (20 ml) was added to the residue,And distilled water (15 ml) were added and extracted.Further, the aqueous layer was extracted twice with ethyl acetate (15 ml).The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate.The solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography(Hexane: ethyl acetate = 3: 1 – 1: 1)4- (4-phenyl-1-piperazinyl) -thieno [2,3-d]Pyrimidine as a brown solid (148 mg, 54%).Toluene (20 ml) and 1 N HCl aqueous solution (0.6 ml) were added to the obtained solid, and the mixture was heated under reflux for 1 hour. After cooling the reaction solution to room temperature, suction filtration was carried out,4- (4-methyl-1-piperazinyl) -thieno [2,3-d] pyrimidine hydrochloride (127 mg, 45%)As a brown solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 14080-59-2, 4-Chlorothieno[2,3-d]pyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CHIBA UNIVERSITY; JUNTENDO; HOSHINO, TYUJI; YANAGITA, HIROSHI; YAMAMOTO, NORIO; (17 pag.)JP5765650; (2015); B2;,
Pyrimidine | C4H4N2 – PubChem,
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