The origin of a common compound about 4212-49-1

Statistics shows that 4212-49-1 is playing an increasingly important role. we look forward to future research findings about 5-Ethyluracil.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4212-49-1, name is 5-Ethyluracil, molecular formula is C6H8N2O2, molecular weight is 140.14, as common compound, the synthetic route is as follows.4212-49-1

Step A: Synthesis of 2,4-dichloro-5-ethylpyrimidine. To a suspension of 5-ethyluracil (1 g, 7.1 mmol) in POCl3 (4.5 mL) was slowly added N,N-dimethylaniline (1 mL). The reaction was heated at reflux (~120 C) for 5 h until the starting material was completely dissolved and the entire solution turned a purple color. The mixture was allowed to cool and poured very slowly into ice (~40 g). The resulting ppt was filtered and washed with ice water. The ppt was dissolved with a minimal amount of DCM and poured onto a short column of silica gel, and the product (1.2 g, ~ 100 %) was obtained by column chromatography with DCM. 1H NMR (400 MHz, CDCl3) delta 8.42 (s, 1 H), 2.75 (q, 2 H, J = 7.6 Hz), 1.29 (t, 3 H, J = 7.6 Hz).

Statistics shows that 4212-49-1 is playing an increasingly important role. we look forward to future research findings about 5-Ethyluracil.

Reference:
Patent; Taisho Pharmaceutical Co. Ltd.; Arena Pharmaceuticals, Inc.; EP1464335; (2004); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia