Related Products of 4270-27-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4270-27-3, name is 6-Chloropyrimidine-2,4(1H,3H)-dione, molecular formula is C4H3ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a suspension of 6-chlorouracil (17.58 g, 120 mmol) in DMF (60 mL) were added DIPEA (27.2 mL, 156 mmol) and 1-bromo-2-butyne (12 mL, 132 mmol). The reaction mixture was stirred overnight at r.t. Water was added. The precipitate was collected by filtration, washed with water and EtOH, and dried to give 5b as a light yellow solid (21 g, 88%).
According to the analysis of related databases, 4270-27-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Lai, Zeng-Wei; Li, Chunhong; Liu, Jun; Kong, Lingyi; Wen, Xiaoan; Sun, Hongbin; European Journal of Medicinal Chemistry; vol. 83; (2014); p. 547 – 560;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia