Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 115093-90-8, name is 4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine. A new synthetic method of this compound is introduced below., Computed Properties of C6H3Cl2N3
General procedure: The 4,5-dichloro-7H-pyrrolo[2,3-d]pyrimidine (0.11 mmol) was added to 3-(4- amino-i H-pyrazol -1 -yl)-N-(6-methylpyridin-3 -yl)benzamide (0.1 mmol) in tBuOH (1.0 mL) and stirred at 90 C for 12 h. The solvent was evaporated and the residue was purified by reverse-phase preparative HPLC to give the product.Procedures in Scheme 4 were utilized to synthesize this compound. LC-MS: 445(M+H).
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Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; FENG, Yangbo; LOGRASSO, Philip; ZHENG, Ke; PARK, Chul Min; WO2015/84936; (2015); A1;,
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