Synthetic Route of 1211522-68-7 ,Some common heterocyclic compound, 1211522-68-7, molecular formula is C6H4Cl2N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of ethanol (0.227 g, 4.93 mmol) in THF (60 mL) was added sodium hydride inice bath. After stirred for 20 mm, 4, 6-dichloro-3-methyl-1H-pyrazolo [3,4-d]pyrimidine (1 g,4.93 mmol) was added. The mixture was gradually allowed to room temperature and stirredovernight at room temperature. The mixture was then diluted with water (20 mL),concentrated to remove solvent and diluted with ethyl acetate (220 mL). The organic layerwas washed with water (60 mLx 2), dried over Na2SO4, filtered and concentrated. The crudeproduct (900 mg, 86% yield) was directly used into next step.LCMS: 213[M+H]. tR=2.775 (LCMS condition 1)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1211522-68-7, its application will become more common.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; DING, Xiao; LIU, Qian; LONG, Kai; SANG, Yingxia; STASI, Luigi Piero; WAN, Zehong; XU, Qiongfeng; EDGE, Colin Michael; WO2015/113451; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia