Synthetic Route of 213265-83-9 ,Some common heterocyclic compound, 213265-83-9, molecular formula is C4HCl2FN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Into 3 ml of acetnitrile were added 0.2 g of 4, 6-DICHLORO-5-FLUOROPYRIMIDINE, 0.50 g of pottasium carbonate and 0.27 g of trans-2, 6-DIMETHYLHEXAHYDRO-LH-AZEPINE hydrochloride, and the mixture was stirred for 2 hours at 60 C. The reaction mixture was cooled to near room temperature, a saturated ammonium chloride aqueous solution was added therein, and the mixture was extracted with tert-butyl methyl ether three times. The organic layers were washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography to obtain 0.31 g of 1- (6-CHLORO- 5-fluoropyrimidin-4-yl) -trans-2, 6-DIMETHYLHEXAHYDRO-LH-AZEPI ne. 1H-NMR : 0.92 (d, 3H), 1.19 (d, 3H) 1.44-1. 65 (m, 5H), 1.94-2. 11 (m, 2H), 3.41 (d, 1H), 4.17 (brd, 1H), 4.47-4. 56 (m, 1H) 8.10 (d, 1H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 213265-83-9, 4,6-Dichloro-5-fluoropyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2004/99160; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia