Reference of 1193-21-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1193-21-1 as follows.
EXAMPLE 8 This example illustrates the preparation of (E)-methyl 2-[2-(4-fluoropyrimidin-6-yloxy)phenyl]-3-methoxypropenoate, an intermediate for the synthesis of compounds of the invention. A mixture of 4,6-dichloropyrimidine (6.50 g), sulphur tetrafluoride (20.8 g) and Arcton 113 (35 ml) was heated at 50 C. with stirring in a 100 ml Monel reactor for 3.3 hours. The temperature was increased to 100 C. over 25 minutes and maintained at 100 C. for a further 3 hours. The temperature was increased to 151 C. over 20 minutes and maintained at 151 C. for 3 hours. The vessel was then allowed to cool to room temperature. The reaction mixture was poured into saturated sodium hydrogen carbonate solution and extracted with dichloromethane. A sticky solid was observed at the interface and was removed by filtration. The layers were then separated. The organic layer was washed with water, and then distilled at atmospheric pressure to remove the dichloromethane. 4,6-Difluoropyrimidine was isolated by distillation in vacuo (50 C./100 mmHg) as a light yellow oil (400 mg; 7.3% yield); 1 H NMR delta: 6.61 (1H, s); and 8.69 (1H, s)ppm.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1193-21-1, its application will become more common.
Reference:
Patent; Imperial Chemical Industries PLC; US5145856; (1992); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia