Related Products of 932-52-5 ,Some common heterocyclic compound, 932-52-5, molecular formula is C4H5N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
15.01g (84.73mmol) 5- amino-uracil was dissolved in 100 mL of 20% hydrochloric acid, stirred for half an hour and then was added 13.5ml (163.62mmol) of freshly distilled crotonaldehyde, the reaction was heated at reflux for 5 hours, the reaction solution was dark brown. The reaction mixture was cooled to room temperature, placed in 4 refrigerator cold storage overnight. The precipitated pale yellow solid was filtered off under reduced pressure using a Buchner funnel, and slowly added dropwise with aqueous ammonia and solid was kept under stirring allowed to become homogeneous slurry, aqueous ammonia was added to stop the detection pH of 7 to 8:00, and again filtered and dried to yield 13.22g of compound 7, an off-white solid, yield 63.2%
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 932-52-5, 5-Aminopyrimidine-2,4(1H,3H)-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Beijing University; Liu, Junyi; Zhou, Shouxin; Zhang, Zhili; (18 pag.)CN102977090; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia