Synthetic Route of 59549-51-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 59549-51-8, name is 5-Bromo-2-chloro-4-(methylthio)pyrimidine. A new synthetic method of this compound is introduced below.
5-Bromo-2-chloro-4-(methylthio)pyrimidine (125 mmol, 30 g) was suspended in n-BuOH (300 mL) with 3-chloro-4-fluoroaniline (125 mmol, 18.22 g). The reaction was then treated with 4 N HCl (100 mmol, 25 niL) in dioxane and refluxed at 100 0C for 1.5 h under nitrogen. The reaction was cooled to room temperature, diluted with diethyl ether and the solid was filtered and dried to afford 29 g of (5-bromo-4-methylsulfanyl-pyrimidin-2-yl)-(3-chloro-4- fluoro-phenyl)-amine as a pale yellow solid (83 mmol, 67 %). MS(ES): 348(M) and 350(M+2) for CnH8BrClFN3S.1H-NMR 300MHz DMSO-d6 : delta 2.55 (s, 3H), 7.34 (t, J= 9.0 Hz, IH), 7.56-7.59 (m, IH), 8.08 (t, J= 4.5 Hz, IH), 8.33 (s, IH), 9.98 (s, IH).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,59549-51-8, 5-Bromo-2-chloro-4-(methylthio)pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BORIACK-SJODIN, Ann; CARCANAGUE, Daniel, Robert; DUSSAULT, Daemian, David; HATOUM-MOKDAD, Holia; HULL, Kenneth, Gregory; IOANNIDIS, Georgine; MANCHESTER, John, Irvin; McGUIRE, Helen, Maureen; McKINNEY, David, Charles; STOKES, Suzanne; WO2010/38081; (2010); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia