With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56686-16-9, name is 5-Bromo-2,4-dimethoxypyrimidine, molecular formula is C6H7BrN2O2, molecular weight is 219.04, as common compound, the synthetic route is as follows.Computed Properties of C6H7BrN2O2
A) 5-Chloro-3-(2,4-dimethoxypyrimidin-5-yl)-3-hydroxy-1,3-dihydroindol-2-one A 1.6 M solution of n-butyllithium in hexane (10 ml, 16 mmol) was added dropwise to a solution of 5-bromo-2,4-dimethoxypyrimidine (3.29 g, 15 mmol) in THF (50 ml) at -78 C. After stirring at -78 C. for 0.5 h, a suspension of 5-chloroisatin (1.27 g, 7.0 mmol) in THF (50 ml) was added dropwise. The reaction mixture was allowed to warm to room temperature and then saturated ammonium chloride solution was added. The mixture was extracted three times with ethyl acetate, and the combined organic layers were washed with saturated brine. The organic phase was dried over magnesium sulfate, filtered and concentrated under reduced pressure. Purification by chromatography (silica gel, 50% ethyl acetate in dichloromethane) resulted in 0.97 g of the product.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,56686-16-9, 5-Bromo-2,4-dimethoxypyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Abbott GmbH & Co. KG; US2005/70718; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia