Related Products of 29274-24-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 29274-24-6, name is 5-Chloropyrazolo[1,5-a]pyrimidine. A new synthetic method of this compound is introduced below.
5-Aryl/heteroaryl-ethynyl-pyrazolo[1 ,5-a]pyrimidines (51 )[00143] Under a strong stream of argon, aryltrimethylsilylacetylene, 5-chloro- pyrazolo[1 ,5-a]pyrimidine (1 equivalent), PdCI2(PPh3J2 (5 mol %) and copper (I) iodide (5 mol %) are placed in a vial containing DMF. The mixture is flushed thoroughly with argon and Et3N (4 equivalents) is added through the septum. The reaction mixture is warmed to 60 0C and TBAF (1.1 equivalent) in DMF is added dropwise. The mixture is stirred at 60 0C for 3h, the solvent is evaporated and the residue is purified by flash column chromatography to give the desired product. Yields 20-60%.; Example 1 3-Pyrazolo[1,5-a]pyrimidin-5-ylethynyl-benzonitrile[00177] According to General Procedure 1 , 3-[(trimethylsilyl)ethynyl]benzonitrile is reacted with 5-chloro-pyrazolo[1 ,5-a]pyrimidine to provide the title compound in good yield.1H NMR (CDCI3, TMS) delta: 6.76, 6.98, 7.53, 7.72, 7.88, 8.19, 8.69.LC/MS: (M+H)= 245
At the same time, in my other blogs, there are other synthetic methods of this type of compound,29274-24-6, 5-Chloropyrazolo[1,5-a]pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; MERZ PHARMA GMBH & CO. KGaA; HENRICH, Markus; WEIL, Tanja; NAGEL, Jens; GRAVIUS, Andreas; MUeLLER, Sibylle; KAUSS, Valerjans; ZEMRIBO, Ronalds; FOTINS, Juris; WO2010/63487; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia