Related Products of 1088994-22-2 ,Some common heterocyclic compound, 1088994-22-2, molecular formula is C12H10N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Compound 8 was obtained by the following procedure: 5-methyl-2-(pyrimidin-2- yl)benzoic acid (428mg, 2mmol; prepared according to WO 2008147518), intermediate 1 (500mg, 2mmol) and DIPEA (0.65ml) were dissolved in DCM (5ml) at 0C, then T3P (50% in DCM, 1 .5g) was added. The mixture is stirred at reflux for 8 hours then at RT overnight. The reaction was washed with NaOH 1 M and water, dried (Na2SO4) and evaporated. The crude was purified by silica gel column chromatography (DCM to DCM/MeOH = 95/05) to obtain 180mg of the title compound.MS (ESI); m/z 446 [MH]+ 1 HNMR (CDCI3) delta ppm 8.80-8.77 (m, 1 H) 8.64-8.6 (d, 1 H) 8.36-8.31 (d, 1 H) 8.08- 8.04 (m, 1 H) 7.43-7.17 (m, 3H) 7.08-7.03 (t,1 H) 6.36-6.31 (d, 1 H) 5.79 (bs, 1 H) 5.19-5.1 1 (m, 1 H) 4.00-3.89 (m, 1 H) 3.71 -3.62 (m, 1 H) 3.50-3.39 (m, 1 H) 3.37- 3.21 (m, 1 H) 2.45 (s, 3H) 2.31 -2.24 (dd, 1 H) 1 .99-1 .88 (dt, 1 H) 1 .25-1 .19 (d, 1 H) 0.75-0.68 (d, 1 H) 0.60-0.13 (m, 4H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1088994-22-2, 5-Methyl-2-(pyrimidin-2-yl)benzoicacid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ROTTAPHARM S.P.A.; STASI, Luigi Piero; ROVATI, Lucio; WO2012/104338; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia