Reference of 5018-38-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5018-38-2, name is 4,6-Dichloro-5-methoxypyrimidine, molecular formula is C5H4Cl2N2O, molecular weight is 179, as common compound, the synthetic route is as follows.
Example 36 Synthesis of Compound S 1-23 AND 1-27 To a solution of 4,6-dichloro-5-methoxypyrimidine (5.0 g, 28.24 mmol) in DCE (50 mL) at 0 C. was added aluminum trichloride (7.5 g, 56.4 mmol) in two portions. The reaction mixture was stirred at 0 C. for 10 min, then at 50 C. for 4 hr. The mixture was cooled to 0 C. and aqueous HCl (1 M, 20 mL) followed by methanol (20 mL) were added slowly while stirring vigorously. The mixture was poured into water and extracted with diethyl ether. The combined organic layers were washed with brine, dried over magnesium sulfate, filtered and concentrated. The residue was dried in vacuo to afford 4,6-dichloropyrimidin-5-ol as a beige solid. LC/MS APCI: Calculated 163.95; Observed m/z [M+H]+ 165.1. 1H NMR (DMSO-d6): delta (ppm) 11.67 (s, br, 1H), 8.38 (s, 1H).
Statistics shows that 5018-38-2 is playing an increasingly important role. we look forward to future research findings about 4,6-Dichloro-5-methoxypyrimidine.
Reference:
Patent; Arrien Pharmaceuticals LLC; Vankayalapati, Hariprasad; US2020/131154; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia