Adding a certain compound to certain chemical reactions, such as: 50270-27-4, 2,4,6-Trichloropyrimidine-5-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines
A solution of 40 (6.6 g, 20 mmol) and 5-formyl-2,4,6-trichloropyrimidine (5.85 g, 27.7 mmol) in 80 ml of dry DMF was stirred at RT for 8 hr and slowly diluted with 80 ml of water. The solution produced a solid upon refrigeration for 2 days. The product was isolated by filtration, washed with cold 50percent ethanol (50 ml) and 25percent ethanol (50 ml) and dried in vacuum to yield 8.16 g (96percent) 41 as a colorless solid, mp 205-215 C. (decomp). 1H NMR (DMSO-d6) ?0.88 (t, 3H, J=7.2 Hz, CH3), 1.27 (m, 2H, CH2), 1.48 (m, 2H, CH2), 2.81-2.90 (m, 2H, CH2), 3.71-3.85 (m, 4H, CH2), 4.50 (br. s, 5H, OH, NH, H2O), 7.26 (d, 2H, J=8.4 Hz, ArH), 7.44 (d, 2H, J=8.4 Hz, ArH), 8.62 (s, 1H, 5-H).
The synthetic route of 50270-27-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Epoch Biosciences, Inc.; US6699975; (2004); B2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia