Adding a certain compound to certain chemical reactions, such as: 51940-64-8, Ethyl 2,4-Dichloro-5-pyrimidinecarboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 51940-64-8, blongs to pyrimidines compound. COA of Formula: C7H6Cl2N2O2
DIPEA (3.69 mL, 21.12 mmol) was added dropwise to ethyl2,4-dichloropyrimidine-5-carboxylate(3.89 g, 17.60 mmol) and tert-butyl (4-amino-1-methylcyclohexyl)carbamate (4.02 g, 17.6 mmol)in acetonitrile (80 mL) at 0C over a period of2 min. The reaction mixture was stirred at rt for 16 hand concentrated in vacuo. The resulting crude product was purified by fcc, elution gradient 0 to15 10% EtOAc in petroleum ether, to afford the title compound (6.0 g, 83%) as a pale yellow gum; 1HNMR (400 MHz, CDCb) 1.33 – 1.43 (6H, m), 1.43 – 1.64 (11H, m), 1.70 – 1.82 (lH, m), 1.85 -2.01 (4H, m), 2.17 (lH, s), 4.07-4.24 (2H, m), 4.30-4.42 (2H, m), 8.24- 8.57 (lH, m), 8.67 (lH,s); m/z MH+ 413.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,51940-64-8, its application will become more common.
Reference:
Patent; ASTRAZENECA AB; CANCER RESEARCH TECHNOLOGY LIMITED; FINLAY, Maurice, Raymond, Verschoyle; GOLDBERG, Frederick, Woolf; HOWARD, Martin, Richard; TING, Attilla, Kuan, Tsuei; (145 pag.)WO2019/238929; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia