Synthetic Route of 55583-59-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 55583-59-0, name is 2,5-Diamino-4,6-dichloropyrimidine. A new synthetic method of this compound is introduced below.
In a reaction vessel, 4,6-dichloropyrimidine-2,5-diamine (358 mg, 2.00 mmol), 5′-m-terphenylboronic acid (1.22 g, 4.45 mmol), sodium carbonate (1.06 g) Add ethanol (5 mL) and distilled water (5 mL) to a solution of 10.0 mmol) and tetrakis (triphenylphosphine) palladium (0) (116 mg, 0.100 mmol) in toluene (20 mL) at After stirring for 20 hours under heating and reflux conditions under an argon atmosphere, the reaction solution was cooled to room temperature. Distilled water (5 mL) was added and stirred, and the separated aqueous layer was extracted three times with ethyl acetate (10 mL). Thereafter, the whole organic layer is combined, saturated aqueous sodium chloride solution (10 mL) is added thereto, the mixture is stirred and washed, anhydrous sodium sulfate is added to the separated organic layer for dehydration and the filtrate after filtration is concentrated under reduced pressure The The concentrate thus obtained is purified by flash column chromatography (silica gel, n-hexane / ethyl acetate),4,6-Di ([1,1 ‘: 3′, 1′-terphenyl] -5’-yl) pyrimidine-2,5-diamine(1.01 g, 90% yield).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,55583-59-0, 2,5-Diamino-4,6-dichloropyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Microbial Chemistry Research Foundation; Kumagai, Naoya; Noda, Hidetoshi; Asada, Yasuko; Shibazaki, Masakatsu; (48 pag.)JP2019/64981; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia