Application of 5604-46-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 5604-46-6 as follows.
Step 1: 4-chloro-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine To a mixture of 2-amino-4,6-dichloro-pyrimidine-5-carbaldehyde (1.0 g, 5.2 mmol) and Et3N (0.63 g, 6.2 mmol) in THF (20 mL) and H2O (2 mL) was added hydrazine H2NNH2 (10 g, 0.2 mol). Then the mixture was stirred at room temperature for 1.5 hrs. Then the mixture was concentrated in vacuo. The residue was added H2O and filtered to give 4-chloro-1H-pyrazolo[3,4-d]-pyrimidin-6-ylamine (0.8 g, yield 91%) as a yellow solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5604-46-6, its application will become more common.
Reference:
Patent; Heald, Robert; Price, Stephen; Safina, Brian; Savy, Pascal Pierre Alexandre; Seward, Eileen Mary; Sutherlin, Daniel P.; Waszkowycz, Bohdan; US2012/202785; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia