Related Products of 56181-39-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 56181-39-6, name is 5-Bromo-4-chloropyrimidine. A new synthetic method of this compound is introduced below.
To a mixture of 5-bromo-4-chloro-pyrimidine (77 mg, 398 mumol) and (S)-2-amino-4-((2-(2,2-difluoroethoxy)ethyl) (4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl) butyl)amino) butanoic acid (150 mg, 362 mumol) in THF (2 mL) H2O (0.5 mL) was added NaHCO3 (152 mg, 1.81 mmol) and the resulting mixture was heated to 70 C. for 2 h, cooled to rt, and then concentrated in vacuo to give the title compound that was used without further purification. LCMS (ESI+): m/z=571.3 (M+H)+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,56181-39-6, 5-Bromo-4-chloropyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Pliant Therapeutics, Inc.; CHA, Jacob; DONG, Chengguo; HOM, Timothy; JIANG, Lan; LEFTHERIS, Katerina; LI, Hui; MORGANS, JR., David J.; MUNOZ, Manuel; REILLY, Maureen; ZHENG, Yajun; (232 pag.)US2019/276449; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia