Electric Literature of 57489-77-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 57489-77-7, name is 5,7-Dichloropyrazolo[1,5-a]pyrimidine. A new synthetic method of this compound is introduced below.
Mix 5.0 mmol of 5,7-dichloro-pyrazolo[1,5-a]pyrimidine with 50 mL of 2-propanol solution containing 10 mmol of 1-methylpiperazine and stir.353K heating for 15 hours and then cooling to room temperature;The resulting reaction was extracted with ethyl acetate.The organic phase was taken and the organic phase was washed with water and aqueous sodium chloride and dried over anhydrous Na2SO?Concentrated in vacuo and purified by silica gel column chromatography (hexane: ethyl acetate=10:1)The compound CMPS was obtained.CMPS has the following properties: yellow powder, yield: 67%, melting point: 114-116 C.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,57489-77-7, 5,7-Dichloropyrazolo[1,5-a]pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Liaoning University; Yu Sheng; Xu Liang; Wang Xin; Wang Xiaofang; Liu Bin; (8 pag.)CN110016036; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia