Synthetic Route of 5751-20-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5751-20-2, name is 2-(Methylthio)pyrimidin-4(3H)-one, molecular formula is C5H6N2OS, molecular weight is 142.18, as common compound, the synthetic route is as follows.
To a mixture of HOAc (500 mL) and Ac2O (10 mL) was added compound 2- (methylthio)pyrimidin-4(3H)-one (40 g, 0.28 mol). The resulting mixture was heated at 80 ¡ãC for 30 min to remove any moisture. Then NCS (49 g, 0.37 mol) was added at 50-60 ¡ãC. The resulting mixture was stirred at 50-60 ¡ãC for 24 h. The mixture was then cooled to room temperature and was poured into ice-water (500 mL). The solid formed was collected and was treated with MeOH (100 mL) at reflux. Then the solid was filtered and dried on vacuum to give title compound (24 g, 48percent) as a white solid.
The chemical industry reduces the impact on the environment during synthesis 5751-20-2, I believe this compound will play a more active role in future production and life.
Reference:
Patent; PFIZER INC.; NAIR, Sajiv, Krishnan; PLANKEN, Simon, Paul; WO2012/52948; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia