Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5993-98-6, name is 4-Chloro-2-methyl-6-(trifluoromethyl)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4-Chloro-2-methyl-6-(trifluoromethyl)pyrimidine
To benzyl (7S)-7-methyl-5-(2-(1,3-thiazol-2-yl)benzoyl)-1,2,5-oxadiazepane-2-carboxylate (88 mg) obtained in Step A of Example 84 was added 5.1M hydrogen bromide acetic acid solution (2.0 mL), and the mixture was stirred at room temperature for 1 hr. The solvent was evaporated under reduced pressure, and a mixture of the residue, ethanol (2.0 mL), acetic acid (0.012 mL) and 4-chloro-2-methyl-6-trifluoromethylpyrimidine (43.5 mg) was stirred in a microwave reactor at 150 C. for 0.5 hr. To the reaction mixture was added saturated aqueous sodium hydrogencarbonate solution, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed successively with water and saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (NH, hexane/ethyl acetate), and crystallized (hexane/diisopropyl ether) to give the title compound (45 mg). MS: [M+H]+ 464.0.
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Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KAMEI, Taku; ARIKAWA, Yasuyoshi; OHASHI, Tomohiro; IMAEDA, Toshihiro; FUJIMORI, Ikuo; MIKI, Takashi; YONEMORI, Jinichi; OGURO, Yuya; SUGIMOTO, Takahiro; SETO, Masaki; NISHIDA, Goushi; KAMATA, Makoto; IMOTO, Hiroshi; (132 pag.)US2018/155333; (2018); A1;,
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