Electric Literature of 59989-18-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59989-18-3, name is 5-Ethynylpyrimidine-2,4(1H,3H)-dione, molecular formula is C6H4N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Under argon, cuprous iodide (0.02 mmol, 3.8 mg) and tetraphenylphosphine were used Palladium (0.02 mmol, 23 mg) and 1-octane, 5-ethynyluracil. 4 mmol, 99.6 mg) were added successively to a solution of 4,4-dodecylalkynyl-2,6- (0.2 mmol, 225.8 mg). Triethylamine (5 mL) was injected into the above mixture with a syringe and incubated in an oil bath at 60 C In response to four hours. Thin layer chromatography, until the reaction is complete, the reaction is also added 20mL water quenching reaction. The product was extracted with ether (3 x 40 mL) and the organic phase was washed three times with water (3 x 40 mL). Anhydrous magnesium sulfate drying, vacuum distillation solvent. The crude product was separated and purified by column chromatography, and the eluent was dichloromethane: ethyl acetate = 10: 1, volume ratio. The product was recrystallized from n-pentane as a purple-red solid, 199 mg in 60% yield.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 59989-18-3, 5-Ethynylpyrimidine-2,4(1H,3H)-dione.
Reference:
Patent; Tianjin University; Chen Zhijian; Liu Ping; (17 pag.)CN107056829; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia