Electric Literature of 914612-23-0, Adding some certain compound to certain chemical reactions, such as: 914612-23-0, name is 6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine,molecular formula is C14H14ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 914612-23-0.
Method J (Compound 13)5-Chloro-2-(4-((6-methoxypyridin-3-yl)methylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)benzonitrile A) 6-Benzyl-N-((6-chloropyridin-3-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amineA mixture of 6-benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (2.5 g, 9.6 mmol), 2-chloro-5-aminomethylpyridine (2.7 g, 19 mmol), acetonitrile (10 mL), and N,N-diisopropylethylamine (3.4 mL, 19 mmol) was subjected to microwave irradiation at 180 C. for 2 h. After standing at rt overnight, the precipitated solids were collected by filtration and washed with cold acetonitrile (5 mL×2), and dried to yield a yellow powder (2.8 g, 77%).LC-MS: 366.3 [M+H]+ 1H NMR (400 MHz, d6-DMSO): delta 8.34 (d, 1H, J=2.8 Hz), 8.23 (s, 1H), 7.74 (dd, 1H, J=8.4, 2.8 Hz), 7.45-7.25 (m, 7H), 4.56 (d, 2H, J=6.0 Hz), 3.72 (s, 2H), 3.36 (s, 2H), 2.72-2.62 (m, 4H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 914612-23-0, 6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Wei, Zhi-Liang; O’Mahony, Donogh John Roger; Duncton, Matthew; Kincaid, John; Kelly, Michael G.; Wang, Zhan; US2008/275037; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia