Application of 882670-89-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 882670-89-5, name is 6-Bromopyrido[2,3-d]pyrimidin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.
Synthesis of 6-(3 ,5 -dimethoxyphenyl)pyrido [2,3-d]pyrimidin-2-amine. A mixture of 6-bromopyrido[2,3-d]pyrimidin-2-amine (1.0 g, 4.46 mmol), 3,5- dimethoxyphenylboronic acid (1.2 g, 6.70 mmol), PdC12(dppf) (364 mg, 0.446 mmol) and potassium carbonate (1.8 g, 13.39 mmol) in 1,4-dioxane/water (4 mL/1 mL) was degassed withnitrogen for 5 mm and stirred at 110 C for 30 mm under microwave. The reaction mixture was cooled to RT, and concentrated to afford a crude product, which was purified by silica gel column chromatography (ethyl acetate:petroleum ether = 4: 1) to afford 6-(3,5- dimethoxyphenyl)pyrido[2,3-d]pyrimidin-2-amine as a yellow solid (400 mg, 31%). MS (ES+) C15H14N402 requires: 282, found: 283 [M+H].
According to the analysis of related databases, 882670-89-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.; WO2014/11900; (2014); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia