Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4316-98-7, name is 6-Chloro-4,5-diaminopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 4316-98-7
6-Chloro-8-phenyl-9/-/-purine Experimental procedure taken from Ibrahim et al. [24]. A mixture of 6-chloro-4,5-diaminopyrimidine (1.4 mmol) and ammonium chloride (8.40 mmol) was suspended in POCI3 (10.0 mL). After addition of benzoyl chloride (7.00 mmol) the reaction batch was heated for 24 hours at 100 C. After cooling to room temperature and pouring into ice/water, the mixture was neutralized with ammonia solution (25% v/v) to pH 7-8. The obtained solid was filtered off and washed with water. The product was used without any further purification. Mp = 254 – 255 C. 1 H-NMR (DMSO-de, 400 MHz): d (ppm) = 7.62 (m, 3H, ArH), 8.29 (m, 2H, ArH), 8.73 (s, 1 H, ArH), 14.4 (s, 1 H, NH). 13C-NMR (DMSO-de, 100 MHz): d (ppm) = 127.3, 128.4 (2C), 131 .6 (2C), 151 .4 (tert. C), 129.2 (quart. C).
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Reference:
Patent; KTB TUMORFORSCHUNGSGESELLSCHAFT MBH; KUBBUTAT, Michael; SCHAeCHTELE, Christoph; EHLERT, Jan; TOTZKE, Frank; KUNICK, Conrad; WOeLFEL, Sebastian; WEBER, Holger; WO2014/79545; (2014); A1;,
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