Related Products of 5305-59-9 , The common heterocyclic compound, 5305-59-9, name is 6-Chloropyrimidin-4-amine, molecular formula is C4H4ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: A mixture of 3-chloro-4-(3-fluorobenzyloxy)aniline (5.00 g, 19.86 mmol) and compound 2 (4.17 g, 16.55 mmol) with two drops concd HCl in n-BuOH (30 mL) was heated at 110 C and kept stirring for 3 h. As the mixture cooled, the formed yellow solid was filtered through washing with n-BuOH followed by saturated NaHCO3 aqueous solution. After being dried overnight at vacuum drying oven at 40 C, the solid was purified by column chromatography on silica gel eluted with EtOAc/petroleum ether (1:2) to give 3 as a yellowish green solid (6.18 g, 13.24 mmol, 80% yield).
The synthetic route of 5305-59-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Li, Siyuan; Guo, Chunying; Zhao, Hongli; Tang, Yun; Lan, Minbo; Bioorganic and Medicinal Chemistry; vol. 20; 2; (2012); p. 877 – 885;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia