Synthetic Route of 6299-87-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6299-87-2, name is 6-Hydroxypyrimidine-4-carboxylic acid. A new synthetic method of this compound is introduced below.
Into a 5-L 4-necked round-bottom flask, purged and maintained with an inert atmosphere of nitrogen, was placed 6-hydroxypyrimidine-4-carboxylic acid (100 g, 713.79 mmol, 1.00 equiv) and methanol (2000 mL), followed by the addition of thionyl chloride (210 g, 2.50 equiv) dropwise with stirring at 0°C. The resulting solution was stirred at 30°C for 1 day and concentrated under vacuum to afford 1 15 g (crude) of methyl 6-hydroxypyrimidine-4-carboxylate as an off-white solid. LCMS [M+H]+ 155.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6299-87-2, its application will become more common.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; VERMA, Vishal; SHORE, Daniel; VOLGRAF, Matthew; ESTRADA, Anthony A.; LYSSIKATOS, Joseph; (153 pag.)WO2018/15410; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
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